Because anything can happen in a coma, it's all up to your imagination, and your imagination can simulate anything it pleases.

Knytt Stories: Coma.
Grand Theft Auto series: Chief of police's coma.
Drawn to Life: Self-explanatory. The part where he wakes up from the coma is also part of a coma.
Super Mario Bros.: Coma.
Super Mario Bros. 2: Coma. Everyone just pretends it was a dream.
Super Mario Bros. 3: This was a coma that Mario had while he was watching live theater.
Super Mario Bros. 4: Coma.
Scribblenauts: Coma in English class.
Super Scribblenauts: Another coma in English class.
Knytt: Coma.
Knytt Underground: Coma.
Knytt Nano: Coma.
OFF: Coma.
Scribblenauts Remix: Coma ported to mobile devices.
Pacman Without A Cause: Really short coma.
Pick Up the Phone Booth and Die: Coma.
Cool Spot: Coma in a future where adverts are inserted into peoples' dreams.
Action 52: 52 comas in a row suffered by a complete imbecile.
Doki Doki Literature Club: Coma.
Hello Neighbor: Coma.
Super Mario World: Coma.
Super Mario World 2: Yoshi's Island: Coma.
Pick Up the Phone Booth and Aisle: Coma.
Sokoban: Coma had by a warehouse keeper who dropped a crate on their head.
Chip's Challenge: Coma.
Chip's Challenge 2: Coma. Apparently having too many nosebleeds can really do something to you.
Chuck's Challenge: Definitely a coma.
Ace Attorney series: Coma.
Chuck's Challenge 3D: Coma.
Ben 10 5D Game Generator: Coma.
Aisle: Coma.
You Have to Put the Ball in the Cup: Coma.
You Have to Put the Ball in the Cup Physical Version: A non-fictional coma.
You Have to Put the Ball in the Cup *DELUXE EDITION*: Deluxe coma.
Cactus Block: Coma.
Cactus Block 2013: See, the Cactus Block coma lasted a long time.
Yellow Jogger Laser Platform Madness: Coma.
Yellow Jogger Laser Platform Madness 2017: The Yellow Jogger is never going to wake up from his coma.
Powerhouse: Coma within a coma.
Every .io game: Coma.
Freedom Planet: Coma.
Mario Bros.: Coma.
Sonic and the Yellow Jogger: Coma.
Metal Gear Solid series: Coma.
Pokemon Blue: Blue coma.
Pokemon Red: Red coma.
Sonic and the Green Jogger: Green coma.
Portal: Coma.
Half-Life: Coma.
Half-Life 3: Coma.
VG2: Coma.
Frank Sinatra in "River, Stay Away From My Door": Coma. Not Frank Sinatra's coma, though.
Tile Studio: Coma.
Tile World: Coma.
Tile Factory: Completely unrelated coma.
Family Feud: Coma.
bbycast: Coma.
Keylugger: Coma.
!!!!!! - The Game That Appears First In Alphabetical Listings: Coma had by a man who was strapped upside-down to a ceiling.
VVVVVV: Coma had by another man who was also strapped upside-down to a ceiling.
Within a Deep Forest: Coma.
ModArchive Story: Coma in .mod format, somehow.
MAS2: Operator Status: Coma.
100 Nano Dragon: Coma.
Tetris: Coma.
Sudoku: Coma.
Pong: Coma, in which the ball is the patient and the paddles are abusive doctors.
Breakout: Coma, where someone's trying to wake the patient by slamming them against a wall.
Snake: Coma.
Super Kaizo World: Coma.
Enough Plumbers: Many comas.
Enough Plumbers 2: Many more comas.
Portal 2: Coma.
Snakes on a Cartesian Plane: Coma.
Undertale: Coma.
NetHack: Coma.
ADOM: Coma.
Mystery Dungeon series: Previous coma, but in Japan.
Pokemon Mystery Dungeon series: Previous coma, but milked for all its worth.
Chocobo's Dungeon series: Previous coma, but... wait, what?
Etrian Mystery Dungeon: What the hell?
Rogue: Coma.
Final Fantasy series: All comas.
Super Smash Bros. series: Basically like, twelve hospitals full of patients who are all simultaneously in comas.
Minecraft: Coma.
Metroid: Coma in space.
Candy Crush Saga: Coma. The person having the coma is being robbed blind.
Super Metroid: Coma in space, and this time you can walljump.
I Wanna Be The Guy: The Movie: The Game: Coma.
Zork: Coma.
Getting Over It: Coma.
Sexy Hiking: Sexier coma.